AMBRA1 and SLC35C1

Data Source:
BioGRID (two hybrid)

		AMBRA1	SLC35C1
Description		autophagy and beclin 1 regulator 1	solute carrier family 35 member C1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	GDP-fucose Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Carbohydrate Transport Lipid Glycosylation Protein O-linked Fucosylation GDP-fucose Import Into Golgi Lumen Negative Regulation Of Notch Signaling Pathway
Pathways		Macroautophagy	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) GDP-fucose biosynthesis Transport of nucleotide sugars
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Axial length ( 24144296) Diastolic blood pressure ( 26969751) Visceral fat ( 22589738)
Interacting Genes		12 interacting genes: BECN1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBE2D3
Entrez ID		55626	55343
HPRD ID		10975	09324
Ensembl ID		ENSG00000110497	ENSG00000181830
Uniprot IDs		A0A075B6T1 Q9C0C7	B3KQH0 Q96A29
PDB IDs
Enriched GO Terms of Interacting Partners?
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