AMBRA1 and MTCH2

Data Source:
HPRD (in vivo)

		AMBRA1	MTCH2
Description		autophagy and beclin 1 regulator 1	mitochondrial carrier 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Positive Regulation Of Apoptotic Process Protein Localization To Mitochondrion
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bitter beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 19079261 26961502 28892062 25673413 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Hypertension ( 31879980) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Pulse pressure ( 27841878) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 27841878)
Interacting Genes		12 interacting genes: BECN1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBE2D3	5 interacting genes: APOC1 ATP5MJ ESR1 GLP1R XRN1
Entrez ID		55626	23788
HPRD ID		10975	14788
Ensembl ID		ENSG00000110497	ENSG00000109919
Uniprot IDs		A0A075B6T1 Q9C0C7	B4DHQ0 Q9Y6C9
PDB IDs
Enriched GO Terms of Interacting Partners?
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