AMBRA1 and CREM

Data Source:
BioGRID (affinity chromatography technology)

		AMBRA1	CREM
Description		autophagy and beclin 1 regulator 1	cAMP responsive element modulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Chromatin Nucleus Transcription Regulator Complex Cytoplasm ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Fatty Acid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Retinoic Acid Receptor Signaling Pathway Rhythmic Process
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		12 interacting genes: BECN1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBE2D3	45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX
Entrez ID		55626	1390
HPRD ID		10975	00444
Ensembl ID		ENSG00000110497	ENSG00000095794
Uniprot IDs		A0A075B6T1 Q9C0C7	Q03060
PDB IDs
Enriched GO Terms of Interacting Partners?
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