DNAH3 and TCIRG1

Data Source:
BioGRID (affinity chromatography technology)

		DNAH3	TCIRG1
Description		dynein axonemal heavy chain 3	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Axonemal Dynein Complex Microtubule Dynein Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Microtubule Motor Activity ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Microtubule-based Movement Cilium-dependent Cell Motility	Autophagosome Assembly Ossification Osteoclast Proliferation Cellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Transferrin Transport Ion Transmembrane Transport Memory T Cell Activation T-helper 1 Cell Activation T Cell Homeostasis Neutrophil Degranulation Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation Regulation Of Insulin Secretion Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494) Immune reponse to smallpox (secreted IL-10) ( 22610502) Plateletcrit ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Serum uric acid levels ( 29559957) Systolic blood pressure ( 27841878)	Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)
Interacting Genes			6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3
Entrez ID		55567	10312
HPRD ID		04513	05207
Ensembl ID		ENSG00000158486	ENSG00000110719
Uniprot IDs		B4E1S1 Q8TD57	A0A024R5E5 Q13488
PDB IDs
Enriched GO Terms of Interacting Partners?
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