ZCWPW1 and KMT2E

Data Source:
BioGRID (affinity chromatography technology)

		ZCWPW1	KMT2E
Description		zinc finger CW-type and PWWP domain containing 1	lysine methyltransferase 2E (inactive)
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GO Annotations	Cellular Component	Nucleus Chromosome	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Zinc Ion Binding Methyl-CpG Binding Methylated Histone Binding	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Meiosis I Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Family history of Alzheimer's disease ( 30617256) Hemoglobin levels ( 32327693) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		3 interacting genes: L3MBTL3 MEOX2 VAC14	4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		55063	55904
HPRD ID		15706	10528
Ensembl ID		ENSG00000078487	ENSG00000005483
Uniprot IDs		Q9H0M4	Q8IZD2
PDB IDs		2E61 2RR4	2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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