THG1L and HAVCR2

Data Source:
BioGRID (affinity chromatography technology)

		THG1L	HAVCR2
Description		tRNA-histidine guanylyltransferase 1 like	hepatitis A virus cellular receptor 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Transferase Complex	Immunological Synapse Early Endosome Cell Surface Integral Component Of Membrane Cell Junction
	Molecular Function	TRNA Binding Magnesium Ion Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding TRNA Guanylyltransferase Activity Nucleotidyltransferase Activity Identical Protein Binding	Protein Binding Metal Ion Binding
	Biological Process	TRNA Modification Response To Oxidative Stress TRNA Processing Mitochondrial Fusion Regulation Of Catalytic Activity Protein Homotetramerization TRNA 5'-end Processing Stress-induced Mitochondrial Fusion	Adaptive Immune Response Macrophage Activation Involved In Immune Response Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		tRNA modification in the nucleus and cytosol	Interleukin-2 family signaling
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	Blood protein levels ( 30072576 29875488 28240269) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)
Interacting Genes		7 interacting genes: ELMOD1 LNX1 NTAQ1 PLEKHF2 SDCBP TERF1 UBC	3 interacting genes: APP SEC22A TMEM86A
Entrez ID		54974	84868
HPRD ID		13726	16227
Ensembl ID		ENSG00000113272	ENSG00000135077
Uniprot IDs		B4E366 Q9H8R6 Q9NWX6	Q8TDQ0
PDB IDs		3OTB 3OTC 3OTD 3OTE	5DZL 5F71 6DHB 6TXZ
Enriched GO Terms of Interacting Partners?
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