MKS1 and CACNA1G

Data Source:
HPRD (in vitro)

		MKS1	CACNA1G
Description		MKS transition zone complex subunit 1	calcium voltage-gated channel subunit alpha1 G
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol MKS Complex Ciliary Basal Body	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Neuron Projection Synapse
	Molecular Function	Protein Binding	Voltage-gated Sodium Channel Activity Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Scaffold Protein Binding
	Biological Process	Cilium Assembly Ciliary Basal Body-plasma Membrane Docking	Chemical Synaptic Transmission Response To Nickel Cation Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential SA Node Cell Action Potential AV Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling AV Node Cell To Bundle Of His Cell Signaling Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	NCAM1 interactions
Drugs			Ergocalciferol Enflurane Trimethadione Spironolactone Cinnarizine Ethosuximide Verapamil Zonisamide Nifedipine Mibefradil Flunarizine Methsuximide Cannabidiol Trimebutine Benidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases		Bardet-Biedl syndrome (BBS) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Adventurousness ( 30643258) Alzheimer's disease (cognitive decline) ( 23535033) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Total cholesterol levels ( 30498476)
Interacting Genes		2 interacting genes: DDX24 TMEM67	2 interacting genes: RANBP9 UBQLN4
Entrez ID		54903	8913
HPRD ID		07900	04961
Ensembl ID		ENSG00000011143	ENSG00000006283
Uniprot IDs		A0A0S2Z5Z2 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0	O43497
PDB IDs			6KZO 6KZP
Enriched GO Terms of Interacting Partners?
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