MKS1 and ABCC3

Data Source:
BioGRID (affinity chromatography technology)

		MKS1	ABCC3
Description		MKS transition zone complex subunit 1	ATP binding cassette subfamily C member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol MKS Complex Ciliary Basal Body	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	ATP Binding ABC-type Xenobiotic Transporter Activity Glucuronoside Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity
	Biological Process	Cilium Assembly Ciliary Basal Body-plasma Membrane Docking	Drug Transmembrane Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Glucuronoside Transport Xenobiotic Transport Transmembrane Transport Leukotriene Transport Anion Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	Recycling of bile acids and salts ABC-family proteins mediated transport
Drugs
Diseases		Bardet-Biedl syndrome (BBS) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		2 interacting genes: DDX24 TMEM67	2 interacting genes: MLH1 MTDH
Entrez ID		54903	8714
HPRD ID		07900	06826
Ensembl ID		ENSG00000011143	ENSG00000108846
Uniprot IDs		A0A0S2Z5Z2 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0	O15438 Q86VN9
PDB IDs
Enriched GO Terms of Interacting Partners?
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