FNDC8 and CDK12

Data Source:
BioGRID (affinity chromatography technology)

		FNDC8	CDK12
Description		fibronectin type III domain containing 8	cyclin dependent kinase 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding
	Biological Process		Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways			TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS			Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		6 interacting genes: MAD2L1BP MBLAC1 MCRS1 PIK3R3 SMCO1 ZNF76	9 interacting genes: CLK1 EWSR1 MBP PIN1 POLR2A PRPF40A SRPK2 SRSF1 SRSF2
Entrez ID		54752	51755
HPRD ID		13191	10849
Ensembl ID		ENSG00000073598	ENSG00000167258
Uniprot IDs		Q8TC99	Q9NYV4
PDB IDs			4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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