ING3 and FOXP2

Data Source:
BioGRID (affinity chromatography technology)

		ING3	FOXP2
Description		inhibitor of growth family member 3	forkhead box P2
Image
GO Annotations	Cellular Component	Swr1 Complex Nucleoplasm Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex	Chromatin Nucleus
	Molecular Function	Methylated Histone Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Regulation Of Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Histone H2A Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Caudate Nucleus Development Putamen Development Cerebral Cortex Development Response To Testosterone Negative Regulation Of Transcription, DNA-templated Innate Vocalization Behavior
Pathways		HATs acetylate histones
Drugs
Diseases			Speech-language disorder 1 (SPCH1)
GWAS			Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 27798627) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Self-reported risk-taking behaviour ( 30271922 30181555) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)
Interacting Genes		9 interacting genes: APP BEX5 FBXO25 NR1H2 NR1H3 SIVA1 TEX11 TRIM54 USHBP1	15 interacting genes: CCNC CDK3 CTBP1 CTBP2 FAM124A FOXP1 FOXP4 LNX1 MAPK3 PIN1 RPIA SDCBP SP4 TLE5 TSACC
Entrez ID		54556	93986
HPRD ID		06321	05611
Ensembl ID		ENSG00000071243	ENSG00000128573
Uniprot IDs		B7ZKQ7 Q9NXR8	B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2
PDB IDs		1X4I	2A07 2AS5
Enriched GO Terms of Interacting Partners?
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