POLR2E and FADS1

Data Source:
BioGRID (affinity chromatography technology)

		POLR2E	FADS1
Description		RNA polymerase II, I and III subunit E	fatty acid desaturase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	C-5 Sterol Desaturase Activity Linoleoyl-CoA Desaturase Activity Oxidoreductase Activity Omega-6 Fatty Acid Desaturase Activity Acyl-CoA Delta5-desaturase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway Viral Process RNA Metabolic Process Positive Regulation Of Type I Interferon Production Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Regulation Of Transcription, DNA-templated Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Regulation Of Lipid Metabolic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs			alpha-Linolenic acid Icosapent
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)	Alanine transaminase levels ( 29403010) Aortic valve stenosis ( 32186652) Asthma ( 31959851 32296059 31619474) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 24097068 25961943 20686565) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908 21102463) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Eosinophil counts ( 27863252) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fatty acid desaturase activity (adipose tissue) ( 30453627) Fatty acid desaturase activity (serum) ( 30453627) Glycerophospholipid levels ( 26068415) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 20864672 19060906 25961943 20686565) HDL cholesterol levels ( 28334899) Heart rate ( 23583979) Height ( 25429064) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29615537) Homeostasis model assessment of beta-cell function ( 20081858) Inflammatory bowel disease ( 23128233) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060910 30275531 25961943 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 23281178 23823483 23378610 22916037 20037589 19043545) Metabolite levels (lipid measures) ( 27005778) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494 27863252) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Oleic acid (18:1n-9) levels ( 28298293 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) PR interval ( 32439900) QT interval ( 30679814) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Rheumatoid arthritis ( 30423114 24390342) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Sphingolipid levels ( 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29615537) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 29403010) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 20864672 19060906 25961943 20686565) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		29 interacting genes: CHGB FKBP14 FOS GTF2B GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 UBE2D4 URI1 ZSCAN1	1 interacting genes: XRN1
Entrez ID		5434	3992
HPRD ID		15946	06935
Ensembl ID		ENSG00000099817	ENSG00000149485
Uniprot IDs		B4DJ89 E5KT65 P19388	A0A0A0MR51 O60427
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?