ATP6AP1 and ABCD1

Data Source:
HPRD (in vitro)

		ATP6AP1	ABCD1
Description		ATPase H+ transporting accessory protein 1	ATP binding cassette subfamily D member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase, V1 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Small GTPase Binding	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ABC-type Fatty-acyl-CoA Transporter Activity ATPase Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Cellular PH Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Positive Regulation Of ERK1 And ERK2 Cascade Proton Transmembrane Transport Positive Regulation Of Osteoclast Development	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import
Drugs		Tiludronic acid
Diseases			Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS
Interacting Genes		5 interacting genes: ANG ERBB2 HBA1 NR1I2 RHOU	5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2
Entrez ID		537	215
HPRD ID		02184	02300
Ensembl ID		ENSG00000071553	ENSG00000101986
Uniprot IDs		A0A0C4DGX8 A0A384MQW4 Q15904	P33897
PDB IDs
Enriched GO Terms of Interacting Partners?
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