PLAT and DDHD2

Data Source:
BioGRID (two hybrid)

		PLAT	DDHD2
Description		plasminogen activator, tissue type	DDHD domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Collagen-containing Extracellular Matrix Extracellular Exosome	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane COPII-coated ER To Golgi Transport Vesicle Centriolar Satellite
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Phospholipase Activity Triglyceride Lipase Activity Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway	Phosphatidic Acid Biosynthetic Process Locomotory Behavior Visual Learning Triglyceride Catabolic Process Lipid Droplet Organization Positive Regulation Of Mitochondrial Fission
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Synthesis of PA
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		27 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC VDAC1	2 interacting genes: APP MTNR1A
Entrez ID		5327	23259
HPRD ID		01419	16788
Ensembl ID		ENSG00000104368	ENSG00000085788
Uniprot IDs		B4DN26 P00750	B3KPM6 O94830
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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