TUBA8 and CCT8L2

Data Source:
BioGRID (affinity chromatography technology)

		TUBA8	CCT8L2
Description		tubulin alpha 8	chaperonin containing TCP1 subunit 8 like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Microtubule Cytoskeleton	Chaperonin-containing T-complex
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Anion Channel Activity ATP Binding Calcium-activated Potassium Channel Activity Unfolded Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle	Protein Folding Inorganic Anion Transport Potassium Ion Transmembrane Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cilium Assembly RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Epothilone D Patupilone
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Cerebrospinal T-tau levels ( 28247064)	Celiac disease ( 23936387) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		7 interacting genes: GRM7 LINC01554 MYC PXN SIAH1 TCP1 TCP11L2
Entrez ID		51807	150160
HPRD ID		05763	16708
Ensembl ID		ENSG00000183785	ENSG00000198445
Uniprot IDs		Q9NY65	Q96SF2
PDB IDs
Enriched GO Terms of Interacting Partners?
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