ATP5MC3 and CTLA4

Data Source:
BioGRID (affinity chromatography technology)

		ATP5MC3	CTLA4
Description		ATP synthase membrane subunit c locus 3	cytotoxic T-lymphocyte associated protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Mitochondrial Outer Membrane Integral Component Of Membrane Proton-transporting ATP Synthase Complex, Coupling Factor F(o)	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Lipid Binding	Protein Binding
	Biological Process	ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs			Ipilimumab Tremelimumab
Diseases			Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis
GWAS			Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		5 interacting genes: ABHD16A GLP1R MTNR1A TMEM31 VKORC1	17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK
Entrez ID		518	1493
HPRD ID		04112	00474
Ensembl ID		ENSG00000154518	ENSG00000163599
Uniprot IDs		P48201	P16410
PDB IDs			1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM
Enriched GO Terms of Interacting Partners?
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