MRPS23 and BRIP1

Data Source:
HPRD (in vitro)

		MRPS23	BRIP1
Description		mitochondrial ribosomal protein S23	BRCA1 interacting protein C-terminal helicase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Ribosome Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitochondrial Translational Elongation Mitochondrial Translational Termination	DNA Damage Checkpoint DNA Replication Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases			Fanconi anemia
GWAS		Obstetric antiphospholipid syndrome ( 28424481)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: GSC2 HSPB1 POLR1C PTEN USHBP1	10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1
Entrez ID		51649	83990
HPRD ID		17592	05797
Ensembl ID		ENSG00000181610	ENSG00000136492
Uniprot IDs		Q9Y3D9	Q9BX63
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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