IL23A and NEUROD4

Data Source:
BioGRID (affinity chromatography technology)

		IL23A	NEUROD4
Description		interleukin 23 subunit alpha	neuronal differentiation 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Interleukin-23 Complex	Chromatin Nucleus
	Molecular Function	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-23-mediated Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Amacrine Cell Differentiation Positive Regulation Of Cell Differentiation Neuron Development
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs		Briakinumab Ustekinumab Guselkumab Tildrakizumab Risankizumab
Diseases
GWAS		Axial length ( 24144296) Psoriasis ( 25903422 20953190 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)	Asthma (childhood onset) ( 31036433) Lead levels ( 26025379) Refractive error ( 32231278) Severe influenza A (H1N1) infection ( 26379185) Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		3 interacting genes: IL12RB1 IL23R PEX19	5 interacting genes: GABRB1 LRRN2 MAGEB4 PIN1 TCF4
Entrez ID		51561	58158
HPRD ID		12026	14826
Ensembl ID		ENSG00000110944	ENSG00000123307
Uniprot IDs		Q9NPF7	Q8IW56 Q9HD90
PDB IDs		3D85 3D87 3DUH 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB
Enriched GO Terms of Interacting Partners?
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