PDE2A and SPAG7

Data Source:
BioGRID (two hybrid)

		PDE2A	SPAG7
Description		phosphodiesterase 2A	sperm associated antigen 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane	Nucleus
	Molecular Function	Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Zinc Ion Binding CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Protein Homodimerization Activity 3',5'-cyclic-GMP Phosphodiesterase Activity	Nucleic Acid Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CAMP-mediated Signaling CGMP-mediated Signaling Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		cGMP effects G alpha (s) signalling events
Drugs		Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)	Mean platelet volume ( 27863252)
Interacting Genes			2 interacting genes: ABHD16A LXN
Entrez ID		5138	9552
HPRD ID		04041	10247
Ensembl ID		ENSG00000186642	ENSG00000091640
Uniprot IDs		O00408 Q8IW54	I3L0X5 O75391
PDB IDs		1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ	2CPM
Enriched GO Terms of Interacting Partners?
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