PLA1A and CD47

Data Source:
BioGRID (genetic interference)

		PLA1A	CD47
Description		phospholipase A1 member A	CD47 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Triglyceride Lipase Activity Phospholipase A1 Activity Lipase Activity Phosphatidylserine 1-acylhydrolase Activity	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Lipid Metabolic Process Phosphatidylserine Metabolic Process Lipid Catabolic Process Phosphatidylserine Acyl-chain Remodeling	Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 ATP Export Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		Acyl chain remodelling of PS	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		2 interacting genes: ANXA2 APP	16 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV MTIF3 MUC1 P2RY2 PTK2 PVR RHAG SIRPA SYNE4 THBS1 TMEM167B UBQLN1
Entrez ID		51365	961
HPRD ID		07078	03017
Ensembl ID		ENSG00000144837	ENSG00000196776
Uniprot IDs		G5E9W0 Q53H76	A0A0A1TSG4 Q08722
PDB IDs			2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU
Enriched GO Terms of Interacting Partners?
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