DACT1 and KIAA0586

Data Source:
HPRD (in vivo)

		DACT1	KIAA0586
Description		dishevelled binding antagonist of beta catenin 1	KIAA0586
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex Synapse	Photoreceptor Inner Segment Cytoplasm Centrosome Centriole Ciliary Basal Body
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Kinase C Binding Protein Binding Beta-catenin Binding Histone Deacetylase Binding Protein Kinase A Binding Delta-catenin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Embryonic Hindgut Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nodal Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Beta-catenin-TCF Complex Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Smoothened Signaling Pathway Cilium Assembly Regulation Of Establishment Of Protein Localization
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Colorectal cancer or advanced adenoma ( 30510241) Dentate gyrus granule cell layer volume (corrected for total hippocampal volume) ( 30279459) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Metabolite levels ( 23823483) Occipital lobe volume ( 31396565) Parietal lobe volume ( 31396565)	Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: APPL1 C7orf25 CSNK2B PPP1CC SH3GL2 TK1	2 interacting genes: TSC22D2 UBC
Entrez ID		51339	9786
HPRD ID		09709	11092
Ensembl ID		ENSG00000165617	ENSG00000100578
Uniprot IDs		Q9NYF0	A0A087WYM5 A0A494C171 B4DYW5 B7Z7W7 Q9BVV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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