ECSIT and CNN1

Data Source:
BioGRID (genetic interference)

		ECSIT	CNN1
Description		ECSIT signaling integrator	calponin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding	Actin Binding Protein Binding Calmodulin Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Regulation Of Smooth Muscle Contraction Actomyosin Structure Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	15 interacting genes: ACTA1 ADRB2 CALM1 CCHCR1 COG6 DNMBP FYN MYO1A NCAPD2 PLRG1 PRKCE SYCE1 TFPT TPM3 TUBB
Entrez ID		51295	1264
HPRD ID		12225	02884
Ensembl ID		ENSG00000130159	ENSG00000130176
Uniprot IDs		Q9BQ95	B7Z7E1 P51911 Q53FP8 V9HWA5
PDB IDs			1WYP
Enriched GO Terms of Interacting Partners?
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