ECSIT and CORO2B

Data Source:
BioGRID (affinity chromatography technology)

		ECSIT	CORO2B
Description		ECSIT signaling integrator	coronin 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytoplasm Focal Adhesion Actin Cytoskeleton Membrane
	Molecular Function	Protein Binding	Actin Binding Protein Binding Vinculin Binding Actin Filament Binding Talin Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Regulation Of Glomerular Filtration Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Focal Adhesion Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Stress Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Cognitive performance ( 19734545) PR interval ( 32439900) Systolic blood pressure ( 26969751)
Interacting Genes		52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	4 interacting genes: ACTA1 APPBP2 TSC22D1 VCL
Entrez ID		51295	10391
HPRD ID		12225	05416
Ensembl ID		ENSG00000130159	ENSG00000103647
Uniprot IDs		Q9BQ95	Q9UQ03
PDB IDs
Enriched GO Terms of Interacting Partners?
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