PCNT and HPRT1

Data Source:
HPRD (in vivo)

		PCNT	HPRT1
Description		pericentrin	hypoxanthine phosphoribosyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Microtubule Membrane Centriolar Satellite	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Identical Protein Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Spindle Organization Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Cilium Assembly Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Purine salvage
Drugs			Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome	Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Treatment resistant depression ( 30468137)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		11 interacting genes: AKAP9 CALM1 CALM2 CCP110 CEP55 DISC1 PCM1 TP53BP1 TUBG1 TUBGCP2 TUBGCP3	10 interacting genes: EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PRTFDC1 SDCBP SPG21 SREK1IP1
Entrez ID		5116	3251
HPRD ID		05804	02388
Ensembl ID		ENSG00000160299	ENSG00000165704
Uniprot IDs		O95613	A0A140VJL3 P00492
PDB IDs			1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ
Enriched GO Terms of Interacting Partners?
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