PC and MYO7A

Data Source:
BioGRID (affinity chromatography technology)

		PC	MYO7A
Description		pyruvate carboxylase	myosin VIIA
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Microvillus Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Myosin VII Complex Vesicle Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Stereocilium Base Upper Tip-link Density
	Molecular Function	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Identical Protein Binding ADP Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process	Phagolysosome Assembly Intracellular Protein Transport Actin Filament Organization Lysosome Organization Sensory Organ Development Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament Cellular Protein Localization Eye Photoreceptor Cell Development Mechanoreceptor Differentiation Post-embryonic Animal Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis	The canonical retinoid cycle in rods (twilight vision)
Drugs		Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		Pyruvate carboxylase deficiency	Usher syndrome (US) Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)	Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: GOT1 GOT2 MDH2	12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN
Entrez ID		5091	4647
HPRD ID		02032	02043
Ensembl ID		ENSG00000173599	ENSG00000137474
Uniprot IDs		A0A024R5C5 P11498	Q13402
PDB IDs		3BG3 3BG9	5MV9
Enriched GO Terms of Interacting Partners?
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