CLEC4A and KAT8

Data Source:
BioGRID (affinity chromatography technology)

		CLEC4A	KAT8
Description		C-type lectin domain family 4 member A	lysine acetyltransferase 8
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Mannose Binding Carbohydrate Binding	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Negative Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Plasmacytoid Dendritic Cell Antigen Processing And Presentation Cell Adhesion Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Tumor Necrosis Factor Production CD8-positive, Alpha-beta T Cell Activation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Dectin-2 family	HATs acetylate histones
Drugs
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		2 interacting genes: LMNA PTPN6	12 interacting genes: ATM BAZ2A FOXP3 H4C1 KANSL1 KMT2A MSL3 PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		50856	84148
HPRD ID		05604	11381
Ensembl ID		ENSG00000111729	ENSG00000103510
Uniprot IDs		Q9UMR7	Q9H7Z6
PDB IDs		5B1W 5B1X	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR
Enriched GO Terms of Interacting Partners?
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