AK3 and RFX3

Data Source:
HPRD (two hybrid, in vitro)

		AK3	RFX3
Description		adenylate kinase 3	regulatory factor X3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Chromatin Extracellular Region Nucleus Transcription Regulator Complex
	Molecular Function	Adenylate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	ADP Biosynthetic Process Blood Coagulation Nucleoside Triphosphate Biosynthetic Process Phosphorylation AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process Nucleoside Monophosphate Phosphorylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 26805783 22139419 29403010 20139978) White blood cell count ( 27863252)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)
Interacting Genes		6 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 TRIM54 ZDHHC17	13 interacting genes: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6
Entrez ID		50808	5991
HPRD ID		12439	03215
Ensembl ID		ENSG00000147853	ENSG00000080298
Uniprot IDs		Q7Z4Y4 Q9UIJ7	P48380
PDB IDs		1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?
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