PNPLA8 and FLT4

Data Source:
BioGRID (affinity chromatography technology)

		PNPLA8	FLT4
Description		patatin like phospholipase domain containing 8	fms related receptor tyrosine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Phospholipase Activity Lysophospholipase Activity ATP Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	Prostaglandin Biosynthetic Process Fatty Acid Metabolic Process Cell Death Arachidonic Acid Metabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Linoleic Acid Metabolic Process Phosphatidylethanolamine Catabolic Process Arachidonic Acid Secretion Lipid Homeostasis Triglyceride Homeostasis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Hematopoietic Progenitor Cell Differentiation Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PE	VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Sorafenib Sunitinib Vatalanib TG-100801 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Fostamatinib Selpercatinib
Diseases			Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		JT interval (sulfonylurea treatment interaction) ( 27958378) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 22006218) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576 29875488) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)
Interacting Genes			16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD
Entrez ID		50640	2324
HPRD ID		13741	00636
Ensembl ID		ENSG00000135241	ENSG00000037280
Uniprot IDs		A0A024R746 Q9NP80	P35916
PDB IDs			4BSJ 4BSK
Enriched GO Terms of Interacting Partners?
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