P4HA1 and CD48

Data Source:
BioGRID (biochemical)

		P4HA1	CD48
Description		prolyl 4-hydroxylase subunit alpha 1	CD48 molecule
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding Identical Protein Binding	Antigen Binding Protein Binding Signaling Receptor Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Regulation Of Adaptive Immune Response Defense Response Leukocyte Migration
Pathways		Collagen biosynthesis and modifying enzymes	Cell surface interactions at the vascular wall
Drugs		Ascorbic acid Proline Hydralazine
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		2 interacting genes: MLF2 SUMO2	10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		5033	962
HPRD ID		08901	00177
Ensembl ID		ENSG00000122884	ENSG00000117091
Uniprot IDs		P13674 Q5VSQ6	A0A087X1S7 P09326
PDB IDs		1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB	2EDO
Enriched GO Terms of Interacting Partners?
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