NTHL1 and PKD1

Data Source:
BioGRID (two hybrid)

		NTHL1	PKD1
Description		nth like DNA glycosylase 1	polycystin 1, transient receptor potential channel interacting
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Ion Channel Binding
	Biological Process	Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Adult body size ( 32376654) Longevity ( 20834067)	Appendicular lean mass ( 33097823) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: ERCC5 PCNA SRPK2 TP53	30 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		4913	5310
HPRD ID		04039	03203
Ensembl ID		ENSG00000065057	ENSG00000008710
Uniprot IDs		E5KTI5 P78549	P98161
PDB IDs			1B4R 6A70
Enriched GO Terms of Interacting Partners?
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