MX2 and LSS

Data Source:
BioGRID (affinity chromatography technology)

		MX2	LSS
Description		MX dynamin like GTPase 2	lanosterol synthase
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Dendritic Spine Head Presynapse Postsynaptic Endocytic Zone Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity
	Biological Process	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Defense Response Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Interferon-alpha Regulation Of Nucleocytoplasmic Transport Regulation Of Synapse Structure Or Activity MRNA Transport Defense Response To Virus Regulation Of Cell Cycle Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			R048-8071 Lanosterol
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 32341527 30429480) Parkinson disease and lewy body pathology ( 25663231)	White blood cell count ( 27863252)
Interacting Genes		3 interacting genes: ATRIP EHMT2 PIAS2	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		4600	4047
HPRD ID		01001	02945
Ensembl ID		ENSG00000183486	ENSG00000160285
Uniprot IDs		P20592	B2R694 P48449
PDB IDs		4WHJ 4X0R 5UOT	1W6J 1W6K
Enriched GO Terms of Interacting Partners?
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