KLK12 and SRP54

Data Source:
BioGRID (genetic interference)

		KLK12	SRP54
Description		kallikrein related peptidase 12	signal recognition particle 54
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity	RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	Proteolysis Cornification	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		Formation of the cornified envelope	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269)	Heel bone mineral density ( 30598549) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes			2 interacting genes: RNPS1 SRP19
Entrez ID		43849	6729
HPRD ID		05705	05330
Ensembl ID		ENSG00000186474	ENSG00000100883
Uniprot IDs		A0A024R4M4 B9EGA9 Q9UKR0	P61011
PDB IDs			1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32
Enriched GO Terms of Interacting Partners?
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