ARSB and ADAMTS6

Data Source:
HPRD (in vitro)

		ARSB	ADAMTS6
Description		arylsulfatase B	ADAM metallopeptidase with thrombospondin type 1 motif 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Lysosome Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Cell Surface Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Matrix
	Molecular Function	N-acetylgalactosamine-4-sulfatase Activity Arylsulfatase Activity Metal Ion Binding	Metalloendopeptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Autophagy Lysosome Organization Lysosomal Transport Central Nervous System Development Response To Nutrient Response To PH Regulation Of Epithelial Cell Migration Positive Regulation Of Neuron Projection Development Chondroitin Sulfate Catabolic Process Neutrophil Degranulation Response To Estrogen Response To Methylmercury Colon Epithelial Cell Migration	Kidney Development Cardiac Septum Development Proteolysis Extracellular Matrix Organization Aorta Development Coronary Vasculature Development
Pathways		Glycosphingolipid metabolism The activation of arylsulfatases CS/DS degradation MPS VI - Maroteaux-Lamy syndrome Neutrophil degranulation	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Mucopolysaccharidosis type VI (MPS6); Maroteaux-Lamy syndrome
GWAS		Attention deficit hyperactivity disorder ( 23728934) Birth weight ( 31043758) Blood and toenail selenium levels ( 25343990) Blood protein levels ( 29875488 28240269) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Hippocampal atrophy ( 19668339) Iron status biomarkers ( 19084217) Macular thickness ( 30535121) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Non-word reading ( 30741946) Toenail selenium levels ( 25343990)	Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes			1 interacting genes: SNTA1
Entrez ID		411	11174
HPRD ID		08358	05421
Ensembl ID		ENSG00000113273	ENSG00000049192
Uniprot IDs		A0A024RAJ9 A8K4A0 P15848	Q5IR90 Q9UKP5
PDB IDs		1FSU
Enriched GO Terms of Interacting Partners?
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