LSS and MX2

Data Source:
BioGRID (affinity chromatography technology)

		LSS	MX2
Description		lanosterol synthase	MX dynamin like GTPase 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleus Nuclear Pore Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Dendritic Spine Head Presynapse Postsynaptic Endocytic Zone Membrane
	Molecular Function	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity	GTPase Activity Protein Binding GTP Binding Microtubule Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Defense Response Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Interferon-alpha Regulation Of Nucleocytoplasmic Transport Regulation Of Synapse Structure Or Activity MRNA Transport Defense Response To Virus Regulation Of Cell Cycle Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs		R048-8071 Lanosterol
Diseases
GWAS		White blood cell count ( 27863252)	Cutaneous malignant melanoma ( 32341527) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 32341527 30429480) Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	3 interacting genes: ATRIP EHMT2 PIAS2
Entrez ID		4047	4600
HPRD ID		02945	01001
Ensembl ID		ENSG00000160285	ENSG00000183486
Uniprot IDs		B2R694 P48449	P20592
PDB IDs		1W6J 1W6K	4WHJ 4X0R 5UOT
Enriched GO Terms of Interacting Partners?
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