LSS and SIRT5

Data Source:
BioGRID (proximity labelling technology)

		LSS	SIRT5
Description		lanosterol synthase	sirtuin 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol
	Molecular Function	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Protein-glutaryllysine Deglutarylase Activity NAD+ Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Peptidyl-lysine Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Transcriptional activation of mitochondrial biogenesis
Drugs		R048-8071 Lanosterol	Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
Diseases
GWAS		White blood cell count ( 27863252)	Perceived intensity of sweet substances ( 31005972)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	1 interacting genes: APP
Entrez ID		4047	23408
HPRD ID		02945	06838
Ensembl ID		ENSG00000160285	ENSG00000124523
Uniprot IDs		B2R694 P48449	A0A024R012 Q9NXA8
PDB IDs		1W6J 1W6K	2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJM 6LJN
Enriched GO Terms of Interacting Partners?
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