ACAT1 and CXCR4

Data Source:
BioGRID (affinity chromatography technology)

		ACAT1	CXCR4
Description		acetyl-CoA acetyltransferase 1	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Nucleus Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Potassium Ion Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Identical Protein Binding Ubiquitin Binding
	Biological Process	Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Activation Of MAPK Activity Response To Hypoxia Neuron Migration Epithelial Cell Development Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Brain Development Neuron Recognition Response To Virus Response To Activity Fusion Of Virus Membrane With Host Plasma Membrane Calcium-mediated Signaling Neurogenesis Telencephalon Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Vascular Wound Healing Cellular Response To Drug CXCL12-activated CXCR4 Signaling Pathway Regulation Of Programmed Cell Death Myelin Maintenance Response To Morphine Endothelial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Viral Process Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cardiac Muscle Contraction Cell Chemotaxis Endothelial Tube Morphogenesis Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Dendrite Extension Positive Regulation Of Mesenchymal Stem Cell Migration Response To Ultrasound Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Sulfasalazine Cannabidiol Medical Cannabis Nabiximols	Framycetin AMD-070 Plerixafor Ibalizumab
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 19525953) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: AGXT PDP1 PEX7 PTPRF	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		38	7852
HPRD ID		01946	01217
Ensembl ID		ENSG00000075239	ENSG00000121966
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 P24752	A0A0U3FJG0 A0A0U3GXA9 P61073
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
Enriched GO Terms of Interacting Partners?
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