KCNMA1 and SFTPD

Data Source:
BioGRID (proximity labelling technology)

		KCNMA1	SFTPD
Description		potassium calcium-activated channel subfamily M alpha 1	surfactant protein D
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Postsynaptic Membrane	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle
	Molecular Function	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity	Protein Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Relaxation Of Vascular Associated Smooth Muscle Potassium Ion Transmembrane Transport	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Cellular Protein Metabolic Process Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation By Host Of Symbiont Molecular Function Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell
Pathways		Ca2+ activated K+ channels cGMP effects	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Hydrochlorothiazide Miconazole Diazoxide Halothane Dequalinium Trimebutine	Beta-D-Glucose
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		6 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2	3 interacting genes: DCN DMBT1 MFAP4
Entrez ID		3778	6441
HPRD ID		15967	01522
Ensembl ID		ENSG00000156113	ENSG00000133661
Uniprot IDs		A0A087WZL8 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 S4R453	P35247
PDB IDs		2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A	1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?
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