KCNJ15 and KCNE1

Data Source:
BioGRID (proximity labelling technology)

		KCNJ15	KCNE1
Description		potassium inwardly rectifying channel subfamily J member 15	potassium voltage-gated channel subfamily E regulatory subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Z Disc Membrane Raft
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Yohimbine Butamben	Enflurane Promethazine Miconazole Azimilide
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Height ( 31562340) Metabolite levels ( 23823483) Non-response to antidepressants and depression ( 27622933)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) Hippocampal volume ( 29274321) L-selectin levels ( 25576479) Long QT syndrome ( 32429735) QT interval ( 30679814 29213071 24952745 31217584)
Interacting Genes		6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1	6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A
Entrez ID		3772	3753
HPRD ID		03659	01442
Ensembl ID		ENSG00000157551	ENSG00000180509
Uniprot IDs		Q99712	A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6
PDB IDs			2K21
Enriched GO Terms of Interacting Partners?
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