KCNE1 and KCNJ15

Data Source:
BioGRID (proximity labelling technology)

		KCNE1	KCNJ15
Description		potassium voltage-gated channel subfamily E regulatory subunit 1	potassium inwardly rectifying channel subfamily J member 15
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Z Disc Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Enflurane Promethazine Miconazole Azimilide	Yohimbine Butamben
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) Hippocampal volume ( 29274321) L-selectin levels ( 25576479) Long QT syndrome ( 32429735) QT interval ( 30679814 29213071 24952745 31217584)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Height ( 31562340) Metabolite levels ( 23823483) Non-response to antidepressants and depression ( 27622933)
Interacting Genes		6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1
Entrez ID		3753	3772
HPRD ID		01442	03659
Ensembl ID		ENSG00000180509	ENSG00000157551
Uniprot IDs		A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6	Q99712
PDB IDs		2K21
Enriched GO Terms of Interacting Partners?
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