KCNA1 and LAG3

Data Source:
HPRD (in vitro)

		KCNA1	LAG3
Description		potassium voltage-gated channel subfamily A member 1	lymphocyte activating 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Presynaptic Membrane Neuronal Cell Body Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Transmembrane Transporter Activity Disordered Domain Specific Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	Startle Response Potassium Ion Transport Regulation Of Muscle Contraction Chemical Synaptic Transmission Neuroblast Proliferation Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Cellular Protein Localization Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Positive Regulation Of Voltage-gated Potassium Channel Activity	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		Voltage gated Potassium channels	MHC class II antigen presentation
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases		Episodic ataxias
GWAS			Blood protein levels ( 30072576)
Interacting Genes		16 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	2 interacting genes: CEBPZ CENPJ
Entrez ID		3736	3902
HPRD ID		08885	01077
Ensembl ID		ENSG00000111262	ENSG00000089692
Uniprot IDs		Q09470	P18627
PDB IDs		2AFL
Enriched GO Terms of Interacting Partners?
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