ITGB8 and RRAGD

Data Source:
BioGRID (affinity chromatography technology)

		ITGB8	RRAGD
Description		integrin subunit beta 8	Ras related GTP binding D
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Lysosome Centrosome Cytosol EGO Complex Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex
	Molecular Function	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Heterodimerization Activity GTPase Binding
	Biological Process	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation	Cell Cycle Arrest Cellular Response To Starvation Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010)
Interacting Genes		3 interacting genes: ITGAV TGFB1 VTN	3 interacting genes: CHST15 NOL8 RRAGB
Entrez ID		3696	58528
HPRD ID		05001	12199
Ensembl ID		ENSG00000105855	ENSG00000025039
Uniprot IDs		P26012 Q9BUG9	Q9NQL2
PDB IDs		6DJP 6OM1 6OM2 6UJA 6UJB 6UJC	2Q3F
Enriched GO Terms of Interacting Partners?
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