ITGB8 and PSPH

Data Source:
BioGRID (affinity chromatography technology)

		ITGB8	PSPH
Description		integrin subunit beta 8	phosphoserine phosphatase
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome	Cytoplasm Cytosol Neuron Projection
	Molecular Function	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding	Magnesium Ion Binding Phosphoserine Phosphatase Activity Calcium Ion Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation	In Utero Embryonic Development L-serine Metabolic Process L-serine Biosynthetic Process Response To Mechanical Stimulus Dephosphorylation Response To Nutrient Levels Response To Testosterone
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions	Serine biosynthesis
Drugs			Zinc 3-Phosphono-D-alanine Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 31070104 30837465) Macular telangiectasia type 2 ( 28250457) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		3 interacting genes: ITGAV TGFB1 VTN	1 interacting genes: ATXN1
Entrez ID		3696	5723
HPRD ID		05001	01406
Ensembl ID		ENSG00000105855	ENSG00000146733
Uniprot IDs		P26012 Q9BUG9	A0A024RDL3 P78330
PDB IDs		6DJP 6OM1 6OM2 6UJA 6UJB 6UJC	1L8L 1L8O 1NNL 6HYY 6Q6J
Enriched GO Terms of Interacting Partners?
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