IDO1 and DUSP4

Data Source:
BioGRID (affinity chromatography technology)

		IDO1	DUSP4
Description		indoleamine 2,3-dioxygenase 1	dual specificity phosphatase 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity
	Biological Process	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response Tryptophan Catabolic Process Inflammatory Response Female Pregnancy Tryptophan Catabolic Process To Kynurenine Electron Transport Chain Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD Biosynthetic Process From Tryptophan Swimming Behavior Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process	Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Tryptophan catabolism	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway
Drugs		Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood protein levels ( 29875488)	Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP	19 interacting genes: APP CRMP1 GORASP2 GRIN1 GRIN2D LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655
Entrez ID		3620	1846
HPRD ID		00935	04123
Ensembl ID		ENSG00000131203	ENSG00000120875
Uniprot IDs		A0A348GSI3 P14902	Q13115
PDB IDs		2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6TUE 6V52 6WJY	3EZZ
Enriched GO Terms of Interacting Partners?
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