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IDO1 and ADRB3
Data Source:
HPRD
(in vitro)
IDO1
ADRB3
Description
indoleamine 2,3-dioxygenase 1
adrenoceptor beta 3
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Smooth Muscle Contractile Fiber
Stereocilium Bundle
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Molecular Function
Tryptophan 2,3-dioxygenase Activity
Electron Transfer Activity
Heme Binding
Indoleamine 2,3-dioxygenase Activity
Metal Ion Binding
G Protein-coupled Receptor Activity
Beta-adrenergic Receptor Activity
Protein Binding
Beta3-adrenergic Receptor Activity
Protein Homodimerization Activity
Epinephrine Binding
Norepinephrine Binding
Biological Process
Immune System Process
Positive Regulation Of T Cell Tolerance Induction
Positive Regulation Of Chronic Inflammatory Response
Positive Regulation Of Type 2 Immune Response
Tryptophan Catabolic Process
Inflammatory Response
Female Pregnancy
Tryptophan Catabolic Process To Kynurenine
Electron Transport Chain
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Multicellular Organismal Response To Stress
Kynurenic Acid Biosynthetic Process
'de Novo' NAD Biosynthetic Process From Tryptophan
Swimming Behavior
Negative Regulation Of T Cell Proliferation
Regulation Of Activated T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Carbohydrate Metabolic Process
Generation Of Precursor Metabolites And Energy
Energy Reserve Metabolic Process
Receptor-mediated Endocytosis
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Positive Regulation Of MAPK Cascade
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Tryptophan catabolism
Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Nitric Oxide
Cannabidiol
Medical Cannabis
Nabiximols
Amphetamine
Bethanidine
Olanzapine
Norepinephrine
Nortriptyline
Propranolol
Paroxetine
Trimipramine
Cryptenamine
Alprenolol
Terbutaline
Salmeterol
Pindolol
Formoterol
Salbutamol
Ergoloid mesylate
Isoprenaline
Arbutamine
Amiodarone
Fenoterol
Ephedra sinica root
Mephentermine
Clenbuterol
Oxprenolol
Celiprolol
Nebivolol
Amibegron
Solabegron
Droxidopa
Bufuralol
Bopindolol
Bupranolol
Mirabegron
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Dihydroergocristine
Vibegron
Diseases
GWAS
Blood metabolite levels (
24816252
)
Blood protein levels (
29875488
)
Interacting Genes
5 interacting genes:
APP
DDX24
FBXL17
PPP1R16A
TERF2IP
3 interacting genes:
ADRB2
GNAS
SRC
Entrez ID
3620
155
HPRD ID
00935
00188
Ensembl ID
ENSG00000131203
ENSG00000188778
Uniprot IDs
A0A348GSI3
P14902
A8KAG8
P13945
PDB IDs
2D0T
2D0U
4PK5
4PK6
4U72
4U74
5EK2
5EK3
5EK4
5ETW
5WHR
5WMU
5WMV
5WMW
5WMX
5WN8
5XE1
6AZU
6AZV
6AZW
6CXU
6CXV
6DPQ
6DPR
6E35
6E40
6E41
6E42
6E43
6E44
6E45
6E46
6F0A
6KOF
6KPS
6KW7
6MQ6
6O3I
6PU7
6PZ1
6R63
6TUE
6V52
6WJY
2CDW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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