TNFRSF9 and MUTYH

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF9	MUTYH
Description		TNF receptor superfamily member 9	mutY DNA glycosylase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding Cytokine Binding Signaling Receptor Activity	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Population Proliferation	DNA Repair Base-excision Repair Mismatch Repair Depurination
Pathways		TNFs bind their physiological receptors
Drugs		Urelumab
Diseases			Familial adenomatous polyposis
GWAS		Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Psoriasis ( 25903422 23143594) Rheumatoid arthritis ( 30423114 24390342) Ulcerative colitis ( 28067908 21297633) Waist-hip ratio ( 28552196)	Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		3604	4595
HPRD ID		03767	05380
Ensembl ID		ENSG00000049249	ENSG00000132781
Uniprot IDs		Q07011	D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7
PDB IDs		6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2	1X51 3N5N
Enriched GO Terms of Interacting Partners?
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