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CCN1 and SFTPD
Data Source:
BioGRID
(affinity chromatography technology)
CCN1
SFTPD
Description
cellular communication network factor 1
surfactant protein D
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Region
Collagen Trimer
Extracellular Space
Lysosome
Multivesicular Body
Endoplasmic Reticulum Membrane
Rough Endoplasmic Reticulum
Endocytic Vesicle
Clathrin-coated Endocytic Vesicle
Molecular Function
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Insulin-like Growth Factor Binding
Heparin Binding
Extracellular Matrix Binding
Protein Binding
Carbohydrate Binding
Biological Process
Osteoblast Differentiation
Positive Regulation Of Protein Phosphorylation
Intussusceptive Angiogenesis
Atrioventricular Valve Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Ventricular Septum Development
Chemotaxis
Cell Adhesion
Signal Transduction
Positive Regulation Of Phospholipase Activity
Positive Regulation Of Cell-substrate Adhesion
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Osteoblast Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Wound Healing, Spreading Of Cells
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Atrial Septum Morphogenesis
Negative Regulation Of Cell Death
Chondroblast Differentiation
Chorio-allantoic Fusion
Labyrinthine Layer Blood Vessel Development
Positive Regulation Of Cartilage Development
Regulation Of ERK1 And ERK2 Cascade
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Ceramide Biosynthetic Process
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Receptor-mediated Endocytosis
Respiratory Gaseous Exchange By Respiratory System
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of T Cell Proliferation
Defense Response To Bacterium
Surfactant Homeostasis
Induction Of Bacterial Agglutination
Cellular Protein Metabolic Process
Innate Immune Response
Macrophage Chemotaxis
Lung Alveolus Development
Positive Regulation Of Phagocytosis
Regulation Of Immune Response
Negative Regulation By Host Of Symbiont Molecular Function
Reactive Oxygen Species Metabolic Process
Regulation Of Adhesion Of Symbiont To Host Epithelial Cell
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Signal regulatory protein family interactions
Surfactant metabolism
Regulation of TLR by endogenous ligand
Defective CSF2RB causes SMDP5
Defective CSF2RA causes SMDP4
Drugs
Beta-D-Glucose
Diseases
GWAS
Appendicular lean mass (
33097823
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Lung function (FEV1/FVC) (
30804560
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
5 interacting genes:
CDC42
ITGAV
ITGB5
SMPD2
UBQLN2
3 interacting genes:
DCN
DMBT1
MFAP4
Entrez ID
3491
6441
HPRD ID
09089
01522
Ensembl ID
ENSG00000142871
ENSG00000133661
Uniprot IDs
O00622
Q6FI18
P35247
PDB IDs
4D0Z
4D11
1B08
1M7L
1PW9
1PWB
2GGU
2GGX
2ORJ
2ORK
2OS9
2RIA
2RIB
2RIC
2RID
2RIE
3DBZ
3G81
3G83
3G84
3IKN
3IKP
3IKQ
3IKR
4E52
4M17
4M18
5OXR
5OXS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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