PLCXD3 and RICTOR

Data Source:
BioGRID (two hybrid)

		PLCXD3	RICTOR
Description		phosphatidylinositol specific phospholipase C X domain containing 3	RPTOR independent companion of MTOR complex 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol TORC2 Complex
	Molecular Function	Protein Binding Phosphoric Diester Hydrolase Activity	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Signal Transduction Lipid Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways			PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Metabolite levels ( 23823483)	Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		2 interacting genes: MAGEA11 P4HB	11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1
Entrez ID		345557	253260
HPRD ID		17860	10682
Ensembl ID		ENSG00000182836	ENSG00000164327
Uniprot IDs		B3KXD1 Q63HM9	Q6R327
PDB IDs			5ZCS
Enriched GO Terms of Interacting Partners?
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