BIRC5 and NNMT

Data Source:
BioGRID (biochemical)

		BIRC5	NNMT
Description		baculoviral IAP repeat containing 5	nicotinamide N-methyltransferase
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Cytosol
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	Nicotinamide N-methyltransferase Activity N-methyltransferase Activity Pyridine N-methyltransferase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Protein-containing Complex Localization Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Response To Organonitrogen Compound Animal Organ Regeneration Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Response To Drug
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation	Methylation Nicotinamide salvaging Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Reserpine Berberine LY2181308	Niacin
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)
Interacting Genes		25 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 FBXL7 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 RAN RASA1 XIAP XPO1	3 interacting genes: APP ATF6 BMF
Entrez ID		332	4837
HPRD ID		04520	02478
Ensembl ID		ENSG00000089685	ENSG00000166741
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	P40261 Q6FH49
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH	2IIP 3ROD 5YJF 6B1A 6CHH 6ORR 6PVE 6PVS
Enriched GO Terms of Interacting Partners?
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