HSPA6 and FCGR2B

Data Source:
BioGRID (affinity chromatography technology)

		HSPA6	FCGR2B
Description		heat shock protein family A (Hsp70) member 6	Fc fragment of IgG receptor IIb
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Dendritic Spine Cell Body
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Protein Binding Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Regulation Of Signaling Receptor Activity Viral Process Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Neuron Death Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488 28240269) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) IgG levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Lipid metabolism phenotypes ( 22286219) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Rheumatoid arthritis ( 30423114) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)
Interacting Genes		16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1	15 interacting genes: APCS BLK CRP ERG28 GAB1 GRB2 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PRKCA PTPN11 PTPN6
Entrez ID		3310	2213
HPRD ID		00775	06849
Ensembl ID		ENSG00000173110	ENSG00000072694
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	P31994
PDB IDs		3FE1	2FCB 3WJJ 5OCC
Enriched GO Terms of Interacting Partners?
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