APOF and RAG1

Data Source:
BioGRID (biochemical, biochemical)

		APOF	RAG1
Description		apolipoprotein F	recombination activating 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Low-density Lipoprotein Particle High-density Lipoprotein Particle	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Cholesterol Binding	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Cholesterol Metabolic Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response
Pathways		LDL remodeling	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Axial length ( 24144296) Blood protein levels ( 30072576 29875488)	Rheumatoid arthritis ( 24390342)
Interacting Genes		2 interacting genes: APOA1 APOA2	17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		319	5896
HPRD ID		00137	01556
Ensembl ID		ENSG00000175336	ENSG00000166349
Uniprot IDs		Q13790	P15918
PDB IDs
Enriched GO Terms of Interacting Partners?
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