GPX4 and GAMT

Data Source:
HPRD (in vitro, in vivo)

		GPX4	GAMT
Description		glutathione peroxidase 4	guanidinoacetate N-methyltransferase
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GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Guanidinoacetate N-methyltransferase Activity
	Biological Process	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Creatine metabolism Transcriptional Regulation by MECP2
Drugs		Glutathione Glutathione Glutathione disulfide	Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine
Diseases			Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS) Guanidinoacetate methyltransferase (GAMT) deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: MAPK13 PARK7 PRDX6	7 interacting genes: CSNK2B FOS POT1 RAB24 TERF1 TERF2IP TRIM39
Entrez ID		2879	2593
HPRD ID		11819	03142
Ensembl ID		ENSG00000167468	ENSG00000130005
Uniprot IDs		P36969 Q6PI42	Q14353 V9HWB2
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3	3ORH
Enriched GO Terms of Interacting Partners?
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